RPL12 Antibody (PACO49966)
- SKU:
- PACO49966
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RPL12 Antibody (PACO49966)
The RPL12 Polyclonal Antibody (PAC049966) offered by Assay Genie is a valuable tool for researchers studying RPL12, a ribosomal protein essential for protein synthesis. This antibody, produced in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications.RPL12 is involved in the assembly of ribosomes and plays a crucial role in protein translation. Dysregulation of RPL12 expression has been linked to various diseases, including cancer and genetic disorders.
By targeting RPL12 with this antibody, researchers can investigate its function and potential implications in disease development.This antibody enables the detection and analysis of RPL12 in different cell types, making it suitable for a wide range of research applications in molecular biology and cancer biology. Understanding the role of RPL12 in protein synthesis and disease pathology can lead to important insights for the development of novel therapeutic strategies.
| Antibody Name: | RPL12 Antibody (PACO49966) |
| Antibody SKU: | PACO49966 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human 60S ribosomal protein L12 protein (1-99AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO49966 at dilution of 1:100. |
| Background: | Binds directly to 26S ribosomal RNA. |
| Synonyms: | 60S ribosomal protein L12 (Large ribosomal subunit protein uL11), RPL12 |
| UniProt Protein Function: | RPL12: a ribosomal protein of the L11P family. Located in the cytoplasm. Binds directly to the 26S rRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This protein is a component of the 60S subunit. Protein type: Ribosomal; TranslationChromosomal Location of Human Ortholog: 9q34Cellular Component: cytosol; focal adhesion; membraneMolecular Function: protein binding; rRNA binding; structural constituent of ribosomeBiological Process: cellular protein metabolic process; gene expression; mRNA catabolic process, nonsense-mediated decay; ribosomal large subunit assembly and maintenance; selenium metabolic process; selenocysteine metabolic process; SRP-dependent cotranslational protein targeting to membrane; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription |
| UniProt Protein Details: | |
| NCBI Summary: | Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P30050 |
| NCBI GenInfo Identifier: | 266921 |
| NCBI Gene ID: | 6136 |
| NCBI Accession: | P30050.1 |
| UniProt Secondary Accession: | P30050,Q5VVV2, Q6PB27 |
| UniProt Related Accession: | P30050 |
| Molecular Weight: | 14,199 Da |
| NCBI Full Name: | 60S ribosomal protein L12 |
| NCBI Synonym Full Names: | ribosomal protein L12 |
| NCBI Official Symbol: | RPL12Â Â |
| NCBI Official Synonym Symbols: | L12Â Â |
| NCBI Protein Information: | 60S ribosomal protein L12 |
| UniProt Protein Name: | 60S ribosomal protein L12 |
| UniProt Synonym Protein Names: | |
| Protein Family: | 50S ribosomal protein |
| UniProt Gene Name: | RPL12Â Â |
| UniProt Entry Name: | RL12_HUMAN |
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