The RPL12 Antibody (PAC011908) is a valuable tool for researchers studying the ribosomal protein L12 (RPL12), a critical component of the ribosome involved in protein synthesis. This polyclonal antibody, generated in rabbits, is highly specific for human RPL12 and has been validated for use in Western blot applications.RPL12 plays a key role in coordinating the translation process within the ribosome, making it essential for cellular function and growth. Dysregulation of RPL12 has been linked to diseases such as cancer, where abnormal protein synthesis can drive tumor growth and progression.
By using the RPL12 Antibody, researchers can accurately detect and analyze RPL12 expression in various cell types, aiding in the study of protein synthesis and its role in disease pathogenesis. This antibody is a valuable tool for those investigating molecular mechanisms of cancer and other diseases where protein synthesis is dysregulated.
RPL12: a ribosomal protein of the L11P family. Located in the cytoplasm. Binds directly to the 26S rRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This protein is a component of the 60S subunit. Protein type: Ribosomal; TranslationChromosomal Location of Human Ortholog: 9q34Cellular Component: cytosol; focal adhesion; membraneMolecular Function: protein binding; rRNA binding; structural constituent of ribosomeBiological Process: cellular protein metabolic process; gene expression; mRNA catabolic process, nonsense-mediated decay; ribosomal large subunit assembly and maintenance; selenium metabolic process; selenocysteine metabolic process; SRP-dependent cotranslational protein targeting to membrane; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription
UniProt Protein Details:
NCBI Summary:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
