The RPL12 Polyclonal Antibody (PACO01436) is a valuable tool for researchers studying ribosomal protein L12 (RPL12), a key component of the ribosome involved in protein synthesis. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blotting applications.RPL12 is essential for ribosomal function and is known to play a role in regulating protein translation. Its dysregulation has been linked to various diseases, including cancer and genetic disorders. By targeting RPL12 with this antibody, researchers can investigate its expression and localization in different cell types, providing insight into its function and potential implications in disease pathology.
With its high specificity and sensitivity, the RPL12 Polyclonal Antibody is an indispensable tool for researchers in the fields of molecular biology, biochemistry, and cancer research. By enabling the detection and analysis of RPL12, this antibody opens up new possibilities for understanding the role of this critical ribosomal protein in health and disease.
Antibody Name:
RPL12 Antibody
Antibody SKU:
PACO01436
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human Ribosomal Protein L12.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
RPL12; 60S ribosomal protein L12
UniProt Protein Function:
RPL12: a ribosomal protein of the L11P family. Located in the cytoplasm. Binds directly to the 26S rRNA. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This protein is a component of the 60S subunit. Protein type: Ribosomal; TranslationChromosomal Location of Human Ortholog: 9q34Cellular Component: cytosol; focal adhesion; membraneMolecular Function: protein binding; rRNA binding; structural constituent of ribosomeBiological Process: cellular protein metabolic process; gene expression; mRNA catabolic process, nonsense-mediated decay; ribosomal large subunit assembly and maintenance; selenium metabolic process; selenocysteine metabolic process; SRP-dependent cotranslational protein targeting to membrane; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription
UniProt Protein Details:
NCBI Summary:
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L11P family of ribosomal proteins. It is located in the cytoplasm. The protein binds directly to the 26S rRNA. This gene is co-transcribed with the U65 snoRNA, which is located in its fourth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
