RPA70 Rabbit Monoclonal Antibody (CAB9615)
- SKU:
- CAB9615
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | RPA70 Rabbit Monoclonal Antibody |
SKU: | CAB9615 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human RPE65 (Q16518). |
Sequence: | TIWL EPEV LFSG PRQA FEFP QINY QKYC GKPY TYAY GLGL NHFV PDRL CKLN VKTK ETWV WQEP DSYP SEPI FVSH PDAL EEDD GVVL SVVV SPGA GQKP A |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | p63; BCO3; LCA2; RP20; rd12; mRPE65; sRPE65; RPE65 |
Positive Sample: | Rat eye |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Lipid-anchor, Microsome membrane. |
Calculated MW: | 61kDa |
Observed MW: | 70kDa |
The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital.
Purification Method: | Affinity purification |
Gene ID: | 6121 |
Clone Number: | ARC1659 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |