The ROS1 Polyclonal Antibody (CAB16669) is a valuable tool for research involving the ROS1 protein, a receptor tyrosine kinase implicated in various cancers, particularly non-small cell lung cancer. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been rigorously validated for use in Western blot applications. By specifically binding to the ROS1 protein, this antibody enables researchers to detect and analyze ROS1 expression in different cell types, making it an essential component for studies in oncology and cancer biology.
ROS1, a member of the receptor tyrosine kinase family, is known for its oncogenic potential and has been identified as a driver mutation in certain cancers. Understanding the role of ROS1 in cancer development and progression is critical for developing targeted therapies and personalized treatment strategies. The ROS1 Polyclonal Antibody provides researchers with a reliable tool to investigate the function and regulation of ROS1, ultimately advancing our knowledge of cancer biology and potentially leading to the development of novel therapeutic interventions.
Product Name:
ROS1 Rabbit Polyclonal Antibody
SKU:
CAB16669
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1934-2232 of human ROS1 (NP_002935.2?).
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.
Purification Method:
Affinity purification
Gene ID:
6098
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse brain, using ROS1 antibody (CAB16669) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
