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ROS1 Antibody (PACO51066)

SKU:
PACO51066
Product Type:
Antibody
Reactivity:
Plant - Arabidopsis
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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ROS1 Antibody (PACO51066)

The ROS1 Antibody (PAC051066) is a highly specific tool for research involving the ROS1 protein, a receptor tyrosine kinase implicated in various cancers, particularly non-small cell lung cancer. This polyclonal antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in immunohistochemistry and Western blot applications.ROS1 is known to play a crucial role in cell growth and differentiation, making it a promising target for cancer therapy.

Aberrant activation of ROS1 has been implicated in oncogenic signaling pathways, highlighting its potential as a therapeutic target in personalized cancer treatment strategies. The ROS1 Antibody enables accurate detection and analysis of ROS1 expression levels in tumor tissues, providing valuable insights for cancer research and drug development efforts.

Antibody Name:ROS1 Antibody (PACO51066)
Antibody SKU:PACO51066
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA
Recommended Dilutions:
Species Reactivity:Arabidopsis thaliana
Immunogen:Recombinant Arabidopsis thaliana Protein ROS1 protein (1-320AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Background:Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity. Generates 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) as a primary 5-meC excision intermediate. Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation modifications during the first days of development post-germination. Participates in UV-B induced- and oxidative DNA damage repair.
Synonyms:Protein ROS1 (EC 3.2.2) (DEMETER-like protein 1) (Repressor of silencing 1), ROS1, DML1
UniProt Protein Function:Bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5-meC) and 5-hydroxymethylcytosine (5-hmeC), leaving an apyrimidinic (AP) site that is subsequently incised by the lyase activity (PubMed:25240767). Generates 3'-phosphor-alpha,beta-unsaturated aldehyde (3'-PUA) as a primary 5-meC excision intermediate (PubMed:25228464). Prevents DNA hypermethylation, specifically in the promoter of otherwise silenced loci. May be involved in DNA repair through its nicking activity on methylated DNA. Binds with similar affinity to both methylated and non-methylated DNA. Highly distributive behavior on DNA substrates containing multiple 5-meC residues. Involved with Pol IV in the remodeling of the 5S rDNA chromatin via DNA methylation modifications during the first days of development post-germination. Participates in UV-B induced- and oxidative DNA damage repair (PubMed:24155752).
UniProt Protein Details:
NCBI Summary:A repressor of transcriptional gene silencing. Functions by demethylating the target promoter DNA. Interacts physically with RPA2/ROR1. In the ros1 mutants, an increase in methylation is observed in a number of gene promoters. Among the loci affected by ros1, a few (RD29A and At1g76930) are affected in cytosine methylation in all sequence contexts (CpG, CpNpG or CpNpN), although many others are affected primarily in non-CpG contexts.
UniProt Code:Q9SJQ6
NCBI GenInfo Identifier:42569673
NCBI Gene ID:818224
NCBI Accession:NP_181190.3
UniProt Secondary Accession:Q9SJQ6,Q7Y1X6
UniProt Related Accession:Q9SJQ6
Molecular Weight:
NCBI Full Name:demeter-like 1
NCBI Synonym Full Names:
NCBI Official Symbol:DML1  
NCBI Official Synonym Symbols:AtROS1; demeter-like 1; F1O11.12; F1O11_12; REPRESSOR OF SILENCING1; ROS1  
NCBI Protein Information:demeter-like 1
UniProt Protein Name:Protein ROS1
UniProt Synonym Protein Names:DEMETER-like protein 1; Repressor of silencing 1
Protein Family:Protein
UniProt Gene Name:ROS1  
UniProt Entry Name:ROS1_ARATH

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