The RORC Polyclonal Antibody (CAB10240) is specifically designed for researchers studying the RORC protein, a key transcription factor involved in the differentiation of Th17 cells and regulation of immune responses. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the RORC protein, this antibody enables precise detection and analysis in various cell types, making it an essential tool for studies in immunology and autoimmune disease research.
RORC, also known as RORγt, plays a crucial role in the development and function of Th17 cells, which are involved in inflammatory responses and autoimmune diseases. Understanding the activity of RORC is essential for unraveling the mechanisms underlying immune dysregulation in conditions such as autoimmune disorders, inflammatory bowel disease, and asthma. The RORC Polyclonal Antibody offers researchers a reliable means to investigate the function of RORC and advance our understanding of immune regulation in health and disease.
Product Name:
RORC Rabbit Polyclonal Antibody
SKU:
CAB10240
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 223-312 of human RORC (NP_005051.2).
The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6097
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of Molt-4, using RORC antibody (CAB10240) at 1:800 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
