The ROPN1L Polyclonal Antibody (PAC040094) is a valuable tool for researchers studying ROPN1L, a protein associated with male fertility and sperm function. This antibody, generated in rabbits, shows high specificity and sensitivity for detecting ROPN1L in human samples, making it suitable for Western blot applications. By targeting the ROPN1L protein, this antibody allows for the identification and analysis of ROPN1L expression in various cell types, making it an ideal choice for investigations in reproductive biology and male infertility research.
ROPN1L, also referred to as SLLP1, is a crucial player in male reproductive health, playing a role in sperm capacitation and fertilization. Research into ROPN1L is important for understanding male infertility and developing potential treatments for individuals experiencing fertility issues. By characterizing the function of ROPN1L, scientists can gain insights into the mechanisms underlying sperm motility and fertilization, ultimately leading to advancements in fertility research and potential clinical applications.
Antibody Name:
ROPN1L Antibody (PACO40094)
Antibody SKU:
PACO40094
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Ropporin-1-like protein (1-230AA)
Immunohistochemistry of paraffin-embedded human testis tissue using PACO40094 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human breast cancer using PACO40094 at dilution of 1:100.
Background:
cytoplasm, motile cilium, epithelial cilium movement
Synonyms:
Ropporin-1-like protein (ROPN1-like protein) (AKAP-associated sperm protein), ROPN1L, ASP
UniProt Protein Function:
ROPN1L: a member of the ropporin family. The encoded protein is a sperm protein. It interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Type II regulatory subunit of cAMP-dependent protein kinase (PKARII) also binds to this helix domain of AKAP3, which allows PKARII to be targeted to specific subcellular compartments. It is suggested that sperm contains several proteins that bind to AKAPs in a manner similar to PKARII, and this encoded protein may be one of them. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Jan 2011]Protein type: Protein kinase, regulatory subunitChromosomal Location of Human Ortholog: 5p15.2Cellular Component: cytoplasmMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ropporin family. The encoded protein is present in sperm and interacts with A-kinase anchoring protein, AKAP3, through the amphipathic helix region of AKAP3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2014]
