The ROPN1 Polyclonal Antibody (PAC042198) is a valuable tool for researchers studying ROPN1, a protein known for its role in sperm function and male fertility. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the ROPN1 protein, researchers can detect and analyze its expression in various cell types, making it an ideal choice for studies in reproductive biology and infertility research.
ROPN1 is a key player in sperm development and function, playing a crucial role in processes such as sperm motility and fertilization. Understanding the function and regulation of ROPN1 is essential for unraveling the mysteries of male infertility and developing new approaches for diagnosis and treatment. The ROPN1 Polyclonal Antibody provides researchers with a reliable tool to investigate the role of ROPN1 in fertility issues and pave the way for new advancements in reproductive medicine.
Immunohistochemistry of paraffin-embedded human colon cancer using PACO42198 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO42198 at dilution of 1:100.
Background:
cytoplasm, nucleus, small GTPase mediated signal transduction
Synonyms:
Ropporin-1A (Cancer/testis antigen 91) (CT91) (Rhophilin-associated protein 1A), ROPN1, ROPN1A
UniProt Protein Function:
ROPN1: Belongs to the ropporin family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protein kinase, regulatory subunit; Cancer Testis Antigen (CTA)Chromosomal Location of Human Ortholog: 3q21.1Cellular Component: cytoplasm; nucleusMolecular Function: protein binding
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
