RNF8 Polyclonal Antibody (CAB7302)
- SKU:
- CAB7302
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | RNF8 Polyclonal Antibody |
SKU: | CAB7302 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-485 of human RNF8 (NP_003949.1). |
Sequence: | VHHE QKAS NSSA SQRS LQMF KVTM SRIL RLKI QMQE KHEA VMNV KKQT QKGN SKKV VQME QELQ DLQS QLCA EQAQ QQAR VEQL EKTF QEEE QHLQ GLEI AQGE KDLK QQLA QALQ EHWA LMEE LNRS KKDF EAII QAKN KELE QTKE EKEK MQAQ KEEV LSHM NDVL ENEL QCII CSEY FIEA VTLN CAHS FCSY CINE WMKR KIEC PICR KDIK SKTY SLVL DNCI NKMV NNLS SEVK ERRI VLIR ERKA KRLF |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | hRNF8; RNF8 |
Positive Sample: | HeLa,Jurkat,Mouse brain,Mouse liver,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Midbody, Nucleus, telomere. |
Calculated MW: | 56kDa |
Observed MW: | 60kDa |
The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 9025 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |