The RNF40 Rabbit Monoclonal Antibody (CAB9598) is a valuable tool for research involving RNF40, a key regulator of gene expression and protein stability. This antibody, produced in rabbits, is highly specific to human samples and is validated for use in various applications, including immunofluorescence and immunohistochemistry.RNF40, a ring finger protein, is known for its role in histone H2B monoubiquitination, which is crucial for gene transcription and DNA repair processes. Dysregulation of RNF40 has been linked to various diseases, including cancer and neurological disorders.
By targeting RNF40 with this antibody, researchers can investigate its function in different cellular contexts and explore its potential as a therapeutic target.With its high specificity and versatility, the RNF40 Rabbit Monoclonal Antibody (CAB9598) is an essential tool for scientists conducting research in molecular biology, oncology, and neuroscience. Its ability to detect and analyze RNF40 protein expression in various samples makes it an invaluable resource for unraveling the intricate mechanisms underlying cellular processes and disease pathogenesis.
Product Name:
RNF40 Rabbit Monoclonal Antibody
SKU:
CAB9598
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 231-431 of human RNF40 (O75150).
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9810
Clone Number:
ARC1651
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RNF40 Rabbit mAb (CAB9598) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
