The RNF40 Polyclonal Antibody (CAB6443) is a valuable tool for research involving the Ring Finger Protein 40 (RNF40), a key player in the regulation of gene expression and protein modification. The antibody, produced in rabbits, exhibits high specificity and sensitivity when used with human samples, and has been validated for use in Western blot applications. By binding to RNF40, the antibody enables researchers to detect and analyze this protein in various cell types, making it ideal for studies in molecular biology and cancer research.RNF40 is a crucial component of the ubiquitin-proteasome system, where it plays a role in targeting proteins for degradation and in regulating gene transcription.
Dysregulation of RNF40 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions. Studying the function of RNF40 can provide valuable insights into the mechanisms underlying these diseases and may lead to the development of novel treatment strategies.Overall, the RNF40 Polyclonal Antibody is a valuable tool for researchers looking to investigate the role of RNF40 in cellular processes and disease pathogenesis. Its high specificity, sensitivity, and versatility make it a valuable addition to any laboratory conducting research in the fields of molecular biology, oncology, and beyond.
Product Name:
RNF40 Rabbit Polyclonal Antibody
SKU:
CAB6443
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human RNF40 (NP_055586.1).
The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
9810
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RNF40 antibody (CAB6443) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
