RNF34 Rabbit Polyclonal Antibody (CAB8517)
- SKU:
- CAB8517
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | RNF34 Rabbit Polyclonal Antibody |
SKU: | CAB8517 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human RNF34 (NP_079402.2). |
Sequence: | MKAG ATSM WASC CGLL NEVM GTGA VRGQ QSAF AGAT GPFR FTPN PEFS TYPP AATE GPNI VCKA CGLS FSVF RKKH VCCD CKKD FCSV CSVL QENL RRCS TCHL LQET AFQR PQLM RLKV KDLR QYLI LRNI PIDT CREK EDLV DLVL CHHG LGSE DDMD TSSL NSSR SQTS SFFT RSFF SNYT APSA TMSS FQGE LMDG DQTS RSGV PAQV QSEI TSAN |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | RFI; RIF; RIFF; hRFI; CARP1; CARP-1; RNF34 |
Positive Sample: | U-251MG,LO2,HeLa,BT-474 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Endomembrane system, Nucleus, Nucleus speckle, Peripheral membrane protein, cytosol. |
Calculated MW: | 42kDa |
Observed MW: | 42kDa |
The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 80196 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |