The RNF31 Polyclonal Antibody (CAB14139) is a valuable tool for researchers studying the function of the RNF31 protein, also known as HOIP. RNF31 is a key component of the linear ubiquitin chain assembly complex (LUBAC), which plays a critical role in regulating immune signaling pathways.This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the RNF31 protein, researchers can easily detect and analyze its expression in various cell types, making it an ideal choice for studies in immunology and inflammation research.
Understanding the function of RNF31 is essential for unraveling the complex mechanisms of immune signaling and inflammation regulation. Dysregulation of RNF31 has been linked to various diseases, including cancer, inflammatory disorders, and autoimmune conditions. By utilizing the RNF31 Polyclonal Antibody, researchers can gain valuable insights into the role of RNF31 in these disease processes, potentially leading to the development of targeted therapies.
Product Name:
RNF31 Rabbit Polyclonal Antibody
SKU:
CAB14139
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 500-700 of human RNF31 (NP_060469.4).
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The encoded protein is the E3 ubiquitin-protein ligase component of the linear ubiquitin chain assembly complex. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
55072
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RNF31 antibody (CAB14139) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
