RNF20 Rabbit Polyclonal Antibody (CAB17309)
- SKU:
- CAB17309
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | RNF20 Rabbit Polyclonal Antibody |
SKU: | CAB17309 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RNF20 (NP_062538.5). |
Sequence: | MSGI GNKR AAGE PGTS MPPE KKAA VEDS GTTV ETIK LGGV SSTE ELDI RTLQ TKNR KLAE MLDQ RQAI EDEL REHI EKLE RRQA TDDA SLLI VNRY WSQF DENI RIIL KRYD LEQG LGDL LTER KALV VPEP EPDS DSNQ ERKD DRER GEGQ EPAF SFLA TLAS SSSE EMES QLQE RVES SRRA VSQI VTVY DKLQ EKVE LLSR KLNS GDNL IVEE AVQE LNSF LAQE NMRL QELT DLLQ EKHR TMSQ EFSK LQSK VETA |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | BRE1; BRE1A; hBRE1; RNF20 |
Positive Sample: | U-87MG,22Rv1,293T,OVCAR3,HeLa,mouse kidney,mouse liver,rat kidney,rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 114kDa |
Observed MW: | 114kDa |
The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
Purification Method: | Affinity purification |
Gene ID: | 56254 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |