The RNF170 Polyclonal Antibody (CAB15195) is a vital tool for researchers studying the RNF170 protein, which is involved in protein degradation processes within cells. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for a variety of research applications, particularly Western blot analysis. By binding to the RNF170 protein, this antibody enables precise detection and analysis in different cell types, making it an essential asset for studies in cell biology and protein degradation mechanisms.RNF170 is a key player in the ubiquitin-proteasome system, a critical pathway responsible for regulating protein turnover and maintaining cellular homeostasis.
Dysregulation of this system has been implicated in numerous diseases, including neurodegenerative disorders and cancer. Therefore, exploring the functions of RNF170 is essential for understanding its role in these pathological conditions and identifying potential therapeutic targets for intervention.Overall, the RNF170 Polyclonal Antibody is a valuable resource for researchers seeking to delve deeper into the mechanisms of protein degradation and its implications for various diseases. Its specificity, sensitivity, and versatility make it an indispensable tool for advancing scientific knowledge in the field of cellular biology.
Product Name:
RNF170 Rabbit Polyclonal Antibody
SKU:
CAB15195
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 46-120 of human RNF170 (NP_001153696.1).
This gene encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
81790
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RNF170 Rabbit pAb (CAB15195) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
