The RNF168 Polyclonal Antibody (CAB3556) is a valuable tool for research involving RNF168, a key protein involved in DNA damage response and repair mechanisms. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the RNF168 protein, enabling precise detection and analysis in various cell types, making it an ideal choice for studies in genetics, oncology, and DNA repair pathways.RNF168, a Ring finger protein, plays a crucial role in the DNA damage response by facilitating the recruitment of repair factors to sites of DNA damage, maintaining genome stability and preventing the accumulation of mutations.
Its involvement in these processes makes it a promising target for research into diseases like cancer, genetic disorders, and neurodegenerative diseases. Understanding the function of RNF168 is essential for developing strategies to enhance DNA repair and potentially improve therapeutic interventions in these conditions.
Product Name:
RNF168 Rabbit Polyclonal Antibody
SKU:
CAB3556
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 300-571 of human RNF168 (NP_689830.2).
This gene encodes an E3 ubiquitin ligase protein that contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. The protein is involved in DNA double-strand break (DSB) repair. Mutations in this gene result in Riddle syndrome.
Purification Method:
Affinity purification
Gene ID:
165918
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RNF168 antibody (CAB3556) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
