The RNF148 Polyclonal Antibody (PAC020354) is a valuable tool for researchers studying RNF148, a protein involved in the regulation of immune responses. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the RNF148 protein, this antibody enables the detection and analysis of RNF148 in various cell types, making it a versatile tool for studies in immunology and cancer research.
RNF148 is known for its role in immune regulation, particularly in modulating immune responses and inflammation. Its involvement in these processes highlights its importance in diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By investigating the function of RNF148, researchers can gain insight into potential therapeutic targets for manipulating immune responses in these pathological contexts.
Antibody Name:
RNF148 Antibody (PACO20354)
Antibody SKU:
PACO20354
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:50-1:200
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human RNF148
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20354(RNF148 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20354(RNF148 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
RNF148 (RING finger protein 148) is a 305 amino acid, single-pass membrane protein that contains one PA (protease associated) domain and a single RING-type zinc finger. RNF148 is encoded by a gene that maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance.
Synonyms:
ring finger protein 148
UniProt Protein Function:
RNF148: Protein type: Membrane protein, integral; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7q31.33Cellular Component: integral to membraneMolecular Function: zinc ion binding
