The RNF144A Polyclonal Antibody (CAB17597) is a powerful tool for researchers studying RNF144A, a protein involved in the regulation of cellular processes including protein degradation and immune response modulation. This rabbit-derived antibody is highly specific to human samples and is validated for use in Western blot applications, making it a reliable choice for studies in immunology and cancer research.RNF144A, also known as E3 ubiquitin-protein ligase RNF144A, plays a crucial role in maintaining cellular homeostasis by targeting specific proteins for degradation through the ubiquitin-proteasome pathway. Its involvement in immune regulation suggests potential implications for diseases such as cancer, autoimmune disorders, and inflammatory conditions.
By targeting RNF144A, researchers can gain insights into cellular mechanisms underlying these diseases and potentially develop targeted therapies.By utilizing the RNF144A Polyclonal Antibody (CAB17597), researchers can effectively detect and analyze RNF144A levels in various cell types, allowing for a deeper understanding of its role in cellular processes and disease development. This antibody is a valuable tool for research aimed at unraveling the complexities of immune regulation and protein degradation pathways, paving the way for new therapeutic strategies in the treatment of various diseases.
Product Name:
RNF144A Rabbit Polyclonal Antibody
SKU:
CAB17597
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 52-179 of human RNF144A (NP_055561.2).
This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development.
Purification Method:
Affinity purification
Gene ID:
9781
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RNF144A Rabbit pAb (CAB17597) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
