The RNF138 Polyclonal Antibody (PACO39750) is a valuable tool for researchers studying RNF138, a protein involved in various cellular processes, including protein degradation and regulation. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting RNF138 in human samples, making it reliable for Western blot applications.RNF138, also known as RING finger protein 138, plays a crucial role in protein turnover and cellular homeostasis. Its functions in protein degradation and ubiquitination make it a key player in maintaining proper cellular function and response to stress conditions.
By targeting RNF138, researchers can further explore its role in cellular processes and potential implications in diseases like cancer and neurodegenerative disorders.With its high reactivity and specificity, the RNF138 Polyclonal Antibody (PACO39750) is an essential tool for studying the function and regulation of RNF138 in various biological contexts. Its valuable applications in research make it a must-have for scientists investigating protein degradation pathways and exploring novel therapeutic targets.
Antibody Name:
RNF138 Antibody (PACO39750)
Antibody SKU:
PACO39750
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human E3 ubiquitin-protein ligase RNF138 protein (2-245AA)
Immunohistochemistry of paraffin-embedded human placenta tissue using PACO39750 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO39750 at dilution of 1:100.
Background:
E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway.
Synonyms:
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138), RNF138, NARF
UniProt Protein Function:
RNF138: E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.19Chromosomal Location of Human Ortholog: 18q12.1Cellular Component: nucleusMolecular Function: protein binding; protein kinase binding; single-stranded DNA binding; ubiquitin conjugating enzyme bindingBiological Process: double-strand break repair via homologous recombination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
