The RNF138 Polyclonal Antibody (PAC004538) is a valuable tool for researchers studying RNF138, a protein involved in various cellular processes, including protein degradation and regulation of gene expression. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for applications such as Western blotting and immunohistochemistry.RNF138, also known as Ring finger protein 138, is a key player in cellular pathways that control protein turnover and gene expression. Its role in maintaining cellular homeostasis and regulating important biological processes highlights its importance in cancer biology, neurodegeneration, and other diseases.
By targeting RNF138, researchers can gain insights into these disease mechanisms and potentially identify new therapeutic targets for intervention.The RNF138 Polyclonal Antibody is a reliable tool for detecting and studying RNF138 in various cell types and tissues, providing valuable information for understanding its function and dysregulation in disease states. Its versatility and specificity make it a valuable asset for researchers in the fields of cell biology, molecular biology, and biomedical research.
Antibody Name:
RNF138 Antibody
Antibody SKU:
PACO04538
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the Internal region of human RNF138.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
RNF138; NARF; HSD-4; HSD4; E3 ubiquitin-protein ligase RNF138; Nemo-like kinase-associated RING finger protein; NLK-associated RING finger protein; hNARF; RING finger protein 138
UniProt Protein Function:
RNF138: E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. 2 isoforms of the human protein are produced by alternative splicing.Protein type: EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Ubiquitin ligase; EC 6.3.2.19Chromosomal Location of Human Ortholog: 18q12.1Cellular Component: nucleusMolecular Function: protein binding; protein kinase binding; single-stranded DNA binding; ubiquitin conjugating enzyme bindingBiological Process: double-strand break repair via homologous recombination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
