The RNF103 Polyclonal Antibody (PAC029532) is a valuable tool for researchers studying RNF103, a protein involved in the regulation of cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the RNF103 protein, this antibody enables the detection and analysis of RNF103 in various cell types, making it an ideal choice for studies in cell biology and molecular biology.RNF103, also known as a Ring finger protein, plays a crucial role in mediating protein degradation and signal transduction pathways within cells.
Its involvement in these processes makes it a key player in regulating cellular functions and responses to external stimuli. Research on RNF103 is essential for gaining insights into various cellular mechanisms and pathways, with implications for understanding diseases such as cancer, neurodegenerative disorders, and metabolic conditions.By using the RNF103 Polyclonal Antibody (PAC029532), researchers can further explore the functions and interactions of RNF103, paving the way for new discoveries in cellular biology and potential therapeutic interventions targeting RNF103-related pathways.
RNF103: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.Protein type: EC 6.3.2.-; Membrane protein, multi-pass; Ubiquitin ligase; Ubiquitin conjugating system; Membrane protein, integral; EC 6.3.2.19Chromosomal Location of Human Ortholog: 2p11.2Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membraneMolecular Function: ligase activity; protein binding; ubiquitin-protein ligase activity; zinc ion bindingBiological Process: central nervous system development; ER-associated protein catabolic process; protein ubiquitination
UniProt Protein Details:
NCBI Summary:
The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by elctroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene. [provided by RefSeq, Oct 2011]
