The RND2 Antibody (PAC049950) is a valuable tool for researchers studying RND2, a member of the Rho family of GTPases that plays a key role in cell migration and invasion. This polyclonal antibody, generated in rabbits, has been shown to react specifically with human samples and is optimized for use in Western blot applications. By binding to RND2, this antibody allows for the precise detection and analysis of RND2 expression in various cell types, making it ideal for studies in cancer biology and cell biology.
RND2 is a critical regulator of cell motility and is known to be dysregulated in numerous types of cancer, making it a promising target for anti-cancer therapies. By understanding the function and regulation of RND2, researchers can gain valuable insights into tumor progression and metastasis, potentially leading to the development of novel therapeutic strategies. The RND2 Antibody is a valuable tool for investigating the role of RND2 in cancer biology and exploring its potential as a therapeutic target.
Antibody Name:
RND2 Antibody (PACO49950)
Antibody SKU:
PACO49950
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human Rho-related GTP-binding protein RhoN protein (104-163AA)
Western Blot. Positive WB detected in: Mouse heart tissue, Mouse liver tissue, Mouse brain tissue. All lanes: RND2 antibody at 2µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 26 kDa. Observed band size: 26 kDa..
Background:
May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily (By similarity).
Synonyms:
Rho-related GTP-binding protein RhoN (Rho family GTPase 2) (Rho-related GTP-binding protein Rho7) (Rnd2), RND2, ARHN RHO7
UniProt Protein Function:
RND2: May be specifically involved in neuronal and hepatic functions. Is a C3 toxin-insensitive member of the Rho subfamily. Belongs to the small GTPase superfamily. Rho family.Protein type: G protein; G protein, monomeric; G protein, monomeric, RhoChromosomal Location of Human Ortholog: 17q21.31Molecular Function: GTPase activity; protein bindingBiological Process: signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin cytoskeleton organization in response to extracellular growth factors. This particular family member has been implicated in the regulation of neuronal morphology and endosomal trafficking. The gene localizes to chromosome 17 and is the centromeric neighbor of the breast-ovarian cancer susceptibility gene BRCA1. [provided by RefSeq, Jul 2008]
