The RNAse L Polyclonal Antibody (CAB9840) is a valuable tool for researchers studying RNAse L, a key enzyme involved in the innate immune response against viral infections. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to RNAse L, this antibody allows for the detection and analysis of RNAse L protein levels in a variety of cell types, making it an essential reagent for research in virology and immunology.RNAse L is a crucial component of the antiviral defense mechanism in cells, as it degrades viral RNA to inhibit viral replication and spread.
Dysregulation of RNAse L function has been implicated in various viral infections and autoimmune disorders, highlighting its importance in the immune response. Researchers studying RNAse L with this antibody may uncover new insights into viral pathogenesis and immune system function, ultimately leading to the development of novel antiviral therapies and immunomodulatory treatments.
Product Name:
RNASEL Rabbit Polyclonal Antibody
SKU:
CAB9840
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 472-741 of human RNASEL (NP_066956.1).
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. The protein is involved in innate immunity and is active against multiple RNA viruses, including the influenza and SARS-CoV-2 viruses. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.
Purification Method:
Affinity purification
Gene ID:
6041
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using RNASEL antibody (CAB9840) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
