RNASEH2A Rabbit Polyclonal Antibody (CAB15132)
- SKU:
- CAB15132
- Product Type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | RNASEH2A Rabbit Polyclonal Antibody |
SKU: | CAB15132 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human RNASEH2A (NP_006388.2). |
Sequence: | MDLS ELER DNTG RCRL SSPV PAVC RKEP CVLG VDEA GRGP VLGP MVYA ICYC PLPR LADL EALK VADS KTLL ESER ERLF AKME DTDF VGWA LDVL SPNL ISTS MLGR VKYN LNSL SHDT ATGL IQYA LDQG VNVT QVFV DTVG MPET YQAR LQQS FPGI EVTV KAKA DALY PVVS AASI CAKV ARDQ AVKK WQFV EKLQ DLDT DYGS GYPN DPKT KAWL KEHV EPVF GFPQ FVRF SWRT AQTI LEKE AEDV IWED SASE NQEG LRKI TSYF LNEG SQAR PRSS HRYF LERG LESA TSL |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | AGS4; JUNB; RNHL; RNHIA; THSD8; RNASEHI; RNASEH2A |
Positive Sample: | rat ovary,rat testis,rat liver |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus. |
Calculated MW: | 33kDa |
Observed MW: | 33kDa |
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
Purification Method: | Affinity purification |
Gene ID: | 10535 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |