The RNASEH2A Polyclonal Antibody (CAB15132) is a valuable tool for researchers studying RNASEH2A, a protein involved in DNA replication and repair processes. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the RNASEH2A protein, researchers can effectively detect and analyze its expression in various cell types, making it a key asset for studies in molecular biology and genetics.RNASEH2A is a critical enzyme that plays a crucial role in maintaining genomic stability by removing RNA fragments from DNA.
Dysregulation of RNASEH2A has been linked to various diseases, including Aicardi-Goutieres syndrome and lupus. Understanding the function and regulation of RNASEH2A is essential for developing targeted therapies for these conditions and advancing our knowledge of DNA repair mechanisms.Overall, the RNASEH2A Polyclonal Antibody is a reliable tool for researchers seeking to investigate the role of RNASEH2A in DNA replication, repair, and disease pathogenesis. Its high specificity and sensitivity make it a valuable resource for advancing research in molecular genetics and biomedicine.
Product Name:
RNASEH2A Rabbit Polyclonal Antibody
SKU:
CAB15132
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-299 of human RNASEH2A (NP_006388.2).
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.
Purification Method:
Affinity purification
Gene ID:
10535
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RNASEH2A Rabbit pAb (CAB15132) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
