Anti-FAM65B Antibody (CAB9234)
- SKU:
- CAB9234
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Anti-FAM65B Antibody (CAB9234)
The FAM65B Polyclonal Antibody (CAB9234) is a valuable tool for researchers studying FAM65B, a protein involved in regulating cell adhesion and migration. This antibody, produced in rabbits, exhibits high specificity for human samples and has been validated for use in Western blot experiments. By binding to FAM65B, researchers can easily detect and analyze this protein in a variety of cell types, making it ideal for studies in cell biology and cancer research.FAM65B, also known as FAM65B 5, plays a crucial role in controlling cell movement and adhesion, making it essential for processes such as wound healing and tumor metastasis.
Understanding the function of FAM65B is key to developing therapies that target cell migration in diseases like cancer and inflammatory disorders. By using the FAM65B Polyclonal Antibody, researchers can gain valuable insights into the role of FAM65B in cellular processes and its potential as a therapeutic target.
| Antibody Name: | Anti-FAM65B Antibody |
| Antibody SKU: | CAB9234 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human FAM65B (NP_056948.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | U-87MG, Mouse thymus, Mouse brain, Rat thymus, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human FAM65B (NP_056948.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MLVG SQSF SPGG PNGI IRSQ SFAG FSGL QERR SRCN SFIE NSSA LKKP QAKL KKMH NLGH KNNN PPKE PQPK RVEE VYRA LKNG LDEY LEVH QTEL DKLT AQLK DMKR NSRL GVLY DLDK QIKT IERY MRRL EFHI SKVD ELYE AYCI QRRL QDGA SKMK QAFA TSPA SKAA RESL TEIN RSFK EYTE NMCT IEVE LENL LGEF SIKM KG |
| Gene ID: | 9750 |
| Uniprot: | Q9Y4F9 |
| Cellular Location: | Cell projection, Cytoplasm, Mitochondrion, cytoskeleton, filopodium, stereocilium membrane |
| Calculated MW: | 65kDa/118kDa |
| Observed MW: | 118kDa |
| Synonyms: | RIPOR2, C6orf32, DFNB104, DIFF40, DIFF48, FAM65B, MYONAP, PL48 |
| Background: | This gene encodes an atypical inhibitor of the small G protein RhoA. Inhibition of RhoA activity by the encoded protein mediates myoblast fusion and polarization of T cells and neutrophils. The encoded protein is a component of hair cell stereocilia that is essential for hearing. A splice site mutation in this gene results in hearing loss in human patients. |
| UniProt Protein Function: | FAM65B: Isoform 2 play a role in promoting myogenic cell differentiation, cytoskeletal rearrangement and filopodia formation. Belongs to the FAM65 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal Chromosomal Location of Human Ortholog: 6p22.3-p21.32 Cellular Component: cytoplasm Molecular Function:protein binding Biological Process: sensory perception of sound Disease: Deafness, Autosomal Recessive 104 |
| NCBI Summary: | The protein encoded by this gene stimulates the formation of a non-mitotic multinucleate syncytium from proliferative cytotrophoblasts during trophoblast differentiation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2013] |
| UniProt Code: | Q9Y4F9 |
| NCBI GenInfo Identifier: | 296439477 |
| NCBI Gene ID: | 9750 |
| NCBI Accession: | Q9Y4F9.4 |
| UniProt Secondary Accession: | Q9Y4F9,Q13529, Q5VV37, Q5VV38, Q9BQ28, A6NHP2, |
| UniProt Related Accession: | Q9Y4F9 |
| Molecular Weight: | 65,692 Da |
| NCBI Full Name: | Protein FAM65B |
| NCBI Synonym Full Names: | family with sequence similarity 65 member B |
| NCBI Official Symbol: | FAM65BÂ Â |
| NCBI Official Synonym Symbols: | PL48; DIFF40; DIFF48; MYONAP; C6orf32; DFNB104Â Â |
| NCBI Protein Information: | protein FAM65B |
| UniProt Protein Name: | Protein FAM65B |
| Protein Family: | Protein |
| UniProt Gene Name: | FAM65BÂ Â |
| UniProt Entry Name: | FA65B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using FAM65B antibody (CAB9234) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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