The RIPK3 Polyclonal Antibody (CAB5431) is a vital tool for scientists studying the RIPK3 protein, a key regulator in cell death pathways and immune responses. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blotting applications.RIPK3, also known as receptor-interacting protein kinase 3, plays a crucial role in mediating programmed cell death and inflammation. Dysregulation of RIPK3 has been implicated in various diseases, including inflammatory disorders and cancer.
By targeting RIPK3, researchers can gain insight into the molecular mechanisms underlying these conditions and potentially develop novel therapeutic strategies.With its ability to detect and analyze RIPK3 in diverse cell types, the RIPK3 Polyclonal Antibody is an invaluable tool for investigations in immunology, oncology, and cell biology. By studying the function and regulation of RIPK3, researchers can advance our understanding of cellular signaling pathways and identify new targets for drug development.
Product Name:
RIPK3 Rabbit Polyclonal Antibody
SKU:
CAB5431
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 21-287 of human RIP3 (NP_006862.2).
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.
Purification Method:
Affinity purification
Gene ID:
11035
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using RIPK3 Rabbit pAb (CAB5431) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
