The RIPK1 Rabbit Monoclonal Antibody (CAB19580) is a cutting-edge research tool designed for studying receptor-interacting serine/threonine-protein kinase 1 (RIPK1), a crucial regulator of cell death and inflammation. This antibody, produced using rabbit monoclonal technology, is highly specific and sensitive, making it ideal for use in various applications such as Western blot, immunohistochemistry, and immunofluorescence.RIPK1 is a key player in the regulation of cell death pathways, including apoptosis, necroptosis, and inflammation. Dysregulation of RIPK1 has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory conditions.
By targeting RIPK1 with this antibody, researchers can investigate its role in disease pathogenesis and potentially identify novel therapeutic targets for intervention.This antibody offers researchers a reliable tool for studying RIPK1 protein expression and function in various cell types and experimental settings. Its high specificity and sensitivity make it a valuable asset for studies in molecular biology, cell signaling, and drug development. By using the RIPK1 Rabbit Monoclonal Antibody (CAB19580), researchers can gain valuable insights into the role of RIPK1 in health and disease, paving the way for the development of new therapeutic strategies.
Product Name:
RIPK1/RIP Rabbit Monoclonal Antibody
SKU:
CAB19580
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 289-490 of human RIPK1/RIP (NP_003795.2).
WB,1:500 - 1:1000 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:
RIP; RIP1; AIEFL; IMD57; RIP-1; RIPK1/RIP
Positive Sample:
Raji,HeLa
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, Cytoplasm.
Calculated MW:
76kDa
Observed MW:
75kDa
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth.
Purification Method:
Affinity purification
Gene ID:
8737
Clone Number:
ARC0059
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RIPK1/RIP Rabbit mAb (CAB19580) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
