The RIN3 Polyclonal Antibody (PACO01453) is a valuable tool for researchers studying RIN3, a protein involved in cellular signaling and membrane trafficking processes. This antibody, produced in rabbits, exhibits high specificity for RIN3 in human samples and has been validated for use in Western blot applications. By binding to the RIN3 protein, this antibody enables the detection and analysis of RIN3 in various cell types, making it an essential reagent for studies in cell biology and signal transduction research.
RIN3 is known for its role in regulating endocytosis and intracellular vesicle trafficking, processes that are crucial for maintaining cellular function and communication. Its involvement in these pathways makes RIN3 a key player in various physiological and pathological conditions, including neurodegenerative diseases and cancer. By investigating the function of RIN3, researchers can gain insight into the mechanisms underlying these disorders and potentially identify new therapeutic targets for intervention.
Antibody Name:
RIN3 Antibody
Antibody SKU:
PACO01453
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human RIN3.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
RIN3; Ras and Rab interactor 3; Ras interaction/interference protein 3
UniProt Protein Function:
Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function.
UniProt Protein Details:
NCBI Summary:
Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
