The RIMS2 Polyclonal Antibody (CAB14990) is a vital tool for researchers studying RIMS2, a protein involved in regulating neurotransmitter release at synapses. This antibody, produced in rabbits, has a high specificity for human samples and has been validated for use in Western blot applications. By binding to the RIMS2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in neuroscience and neurobiology.
RIMS2 is a key player in synaptic transmission, where it functions to promote the release of neurotransmitters like dopamine and glutamate. Understanding the role of RIMS2 is essential in unraveling the mechanisms underlying neurological disorders such as Parkinson's disease, schizophrenia, and Alzheimer's disease. By targeting RIMS2, researchers can uncover potential therapeutic strategies for managing and treating these conditions.
Product Name:
RIMS2 Rabbit Polyclonal Antibody
SKU:
CAB14990
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human RIMS2 (NP_055492.3).
The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis.
Purification Method:
Affinity purification
Gene ID:
9699
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RIMS2 Rabbit pAb (CAB14990) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
