UniProt Protein Function: | RILP: Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17p13.3Cellular Component: phagocytic vesicle membrane; protein complex; mitochondrion; lysosome; lysosomal membrane; late endosome membrane; late endosomeMolecular Function: protein binding; Rab GTPase bindingBiological Process: protein transport; endosome to lysosome transport; antigen processing and presentation of exogenous peptide antigen via MHC class II |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011] |
UniProt Code: | Q96NA2 |
NCBI GenInfo Identifier: | 93204881 |
NCBI Gene ID: | 83547 |
NCBI Accession: | NP_113618.2 |
UniProt Secondary Accession: | Q96NA2,Q71RE6, Q9BSL3, Q9BYS3, B2RBQ8 |
UniProt Related Accession: | Q96NA2 |
Molecular Weight: | 20,726 Da |
NCBI Full Name: | rab-interacting lysosomal protein |
NCBI Synonym Full Names: | Rab interacting lysosomal protein |
NCBI Official Symbol: | RILPÂ Â |
NCBI Official Synonym Symbols: | PP10141Â Â |
NCBI Protein Information: | rab-interacting lysosomal protein |
UniProt Protein Name: | Rab-interacting lysosomal protein |
UniProt Synonym Protein Names: | |
Protein Family: | RILP-like protein |
UniProt Gene Name: | RILPÂ Â |
UniProt Entry Name: | RILP_HUMAN |