The RIG-I/DDX58 Monoclonal Antibody (CAB3689) is a powerful tool for researchers studying the RIG-I/DDX58 protein, a key component of the innate immune system responsible for detecting viral RNA. This monoclonal antibody, generated using advanced technology, specifically targets the RIG-I/DDX58 protein in human samples and is validated for use in various applications, including Western blotting and immunofluorescence.The RIG-I/DDX58 protein is essential for antiviral immune responses, triggering signaling pathways that lead to the production of interferons and other cytokines to combat viral infections.
Research into RIG-I/DDX58 is important for understanding immune responses to viruses and developing antiviral therapies.By using the RIG-I/DDX58 Monoclonal Antibody (CAB3689), researchers can accurately detect and analyze the RIG-I/DDX58 protein in different cell types, providing valuable insights into the mechanisms of innate immunity and potential targets for antiviral strategies. This antibody is a valuable tool for studies in virology, immunology, and infectious diseases.
Product Name:
Rig-I/DDX58 Monoclonal Antibody
SKU:
CAB3689
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthesized peptide derived from human Rig-I/DDX58
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2.
Purification Method:
Affinity purification
Gene ID:
23586
Clone Number:
ARC0824
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Rig-I/DDX58 Rabbit mAb (CAB3689) at 1:1000 dilution.THP-1 cells were treated by LPS (1 μg/ml) at 37℃ for 8 hours.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
