The RIG-I/DDX58 Monoclonal Antibody (CAB23179) is a valuable tool for researchers studying the RIG-I/DDX58 protein, an important player in the innate immune response to viral infections. This antibody, produced using hybridoma technology, specifically targets the RIG-I/DDX58 protein in human samples, making it a reliable tool for various research applications.RIG-I/DDX58 is a key sensor of viral RNA in the cytoplasm, triggering a cascade of signaling events that lead to the production of antiviral proteins and the induction of an immune response. By targeting RIG-I/DDX58 with this antibody, researchers can study the activation and regulation of this signaling pathway in different cell types, providing insights into the mechanisms of antiviral immune responses.
The RIG-I/DDX58 Monoclonal Antibody (CAB23179) is validated for use in Western blot applications, allowing for precise detection and analysis of the RIG-I/DDX58 protein in experimental samples. Its high specificity and sensitivity make it a valuable tool for studies in virology, immunology, and infectious diseases. Researchers interested in understanding the role of RIG-I/DDX58 in antiviral immunity and developing strategies to enhance immune responses against viral infections will benefit from using this antibody in their research.
Product Name:
Rig-I/DDX58 Monoclonal Antibody
SKU:
CAB23179
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 241-455 of human Rig-I/DDX58 (NP_055129.2).
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of the antiviral innate immune response. Mutations in this gene are associated with Singleton-Merten syndrome 2.
Purification Method:
Affinity purification
Gene ID:
23586
Clone Number:
ARC54108
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts from rat liver, using Rig-I/DDX58 Rabbit mAb (CAB23179) at 1:4000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
