The Rictor Polyclonal Antibody (CAB6131) is a valuable tool for researchers studying the protein Rictor, a key component of the mTORC2 complex involved in cell growth and survival pathways. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to Rictor, this antibody allows for precise detection and analysis of the protein in a variety of cell types, making it an essential reagent for investigations in cell signaling, cancer research, and metabolic disorders.
Rictor is essential for the activation of AKT and other downstream signaling molecules, influencing cell proliferation, survival, and metabolism. Dysregulation of mTORC2 signaling, which includes Rictor, has been implicated in various diseases such as cancer, diabetes, and neurodegenerative disorders. By studying Rictor with this antibody, researchers can gain insights into the molecular mechanisms underlying these conditions and potentially identify new therapeutic targets for intervention.
Product Name:
RICTOR Rabbit Polyclonal Antibody
SKU:
CAB6131
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1043-1142 of human RICTOR (NP_689969.2).
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).
Purification Method:
Affinity purification
Gene ID:
253260
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from PC-12 cells, using RICTOR Rabbit pAb (CAB6131) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
