The RIC1 Polyclonal Antibody (PAC046574) is a critical tool for researchers studying RIC1, a protein involved in various cellular processes including cell cycle regulation and proliferation. This antibody is produced in rabbits and has been extensively validated for use in Western blot applications with human samples. By targeting the RIC1 protein, this antibody allows for the detection and analysis of RIC1 expression in different cell types, making it a valuable asset for studies in cancer biology and cell signaling pathways.
RIC1, also known as RAS-Related C3 Botulinum Toxin Substrate 1, is a key player in cellular signaling and communication, particularly in the context of regulating cell growth and division. Dysregulation of RIC1 activity has been linked to various diseases, making it a promising target for therapeutic interventions. Researchers interested in unraveling the molecular mechanisms underlying cancer progression and other disorders will find the RIC1 Polyclonal Antibody indispensable for their experiments.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO46574 at dilution of 1:100.
Immunofluorescent analysis of HepG2 cells using PACO46574 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.
Synonyms:
RAB6A-GEF complex partner protein 1 (Connexin-43-interacting protein of 150 kDa) (Protein RIC1 homolog), RIC1, CIP150 KIAA1432
UniProt Protein Function:
RIC1: Required for phosphorylation and localization of GJA1. Belongs to the RIC1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Adaptor/scaffoldChromosomal Location of Human Ortholog: 9p24.1Cellular Component: cytosol; membrane; protein complex; trans-Golgi network membraneMolecular Function: protein binding; Rab GTPase binding; Rab guanyl-nucleotide exchange factor activityBiological Process: positive regulation of GTPase activity; retrograde transport, endosome to Golgi
