The Rhotekin Polyclonal Antibody (CAB6732) is a valuable tool for researchers studying Rhotekin, a protein involved in intracellular signaling pathways related to cell migration and adhesion. This antibody, generated in rabbits, exhibits high specificity and sensitivity when detecting Rhotekin in human samples, making it an excellent choice for Western blot applications.Rhotekin is a key regulator of Rho GTPase signaling, which plays a critical role in processes such as cell movement, cell-cell adhesion, and cytoskeletal dynamics. Dysregulation of Rho GTPase signaling has been linked to various diseases, including cancer and cardiovascular disorders, highlighting the importance of studying proteins like Rhotekin.
By utilizing the Rhotekin Polyclonal Antibody, researchers can explore the function and regulation of Rhotekin in different cellular contexts, providing valuable insights into its role in normal physiology and disease states. This antibody is a valuable resource for investigations in cell biology, cancer research, and drug development efforts aimed at targeting Rho GTPase signaling pathways.
Product Name:
RTKN Rabbit Polyclonal Antibody
SKU:
CAB6732
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 254-513 of human RTKN (NP_001015056.1).
This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
6242
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RTKN antibody (CAB6732) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
