The Rhodopsin Kinase Polyclonal Antibody (CAB6497) is a valuable tool for researchers studying rhodopsin kinase, a key enzyme involved in the process of visual signal transduction. This antibody, generated in rabbits, exhibits high reactivity specifically with rhodopsin kinase in human samples and has been validated for use in Western blot applications.Rhodopsin kinase is essential for the phosphorylation of rhodopsin, a light-sensitive protein in the retina that initiates the visual cascade. Dysregulation of rhodopsin kinase activity has been implicated in various retinal diseases, including retinitis pigmentosa and night blindness.
By targeting rhodopsin kinase, researchers can gain insight into the mechanisms underlying these conditions and potentially develop targeted therapies.This antibody enables the specific detection and analysis of rhodopsin kinase in a variety of cell types, making it an ideal tool for studies in ophthalmology, vision research, and retinal disorders. By understanding the function and regulation of rhodopsin kinase, researchers can further elucidate the complexities of visual signal transduction and potentially identify novel therapeutic targets for retinal diseases.
Product Name:
GRK1 Rabbit Polyclonal Antibody
SKU:
CAB6497
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human GRK1 (NP_002920.1).
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).
Purification Method:
Affinity purification
Gene ID:
6011
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of Y79 cells, using GRK1 antibody (CAB6497).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
