The RHOC Polyclonal Antibody is a valuable tool for researchers studying the RhoC protein, a key regulator of cell migration and invasion in cancer and other diseases. This antibody, raised in rabbits, is highly specific for human samples and is validated for Western blot applications. It detects the RHOC protein, allowing for detailed analysis in a variety of cell types.RhoC is a member of the Rho GTPase family, known for their roles in cytoskeletal dynamics and cell motility. Aberrant RhoC expression has been linked to tumor progression and metastasis in various cancers, making it an important target for therapeutic interventions.
The RHOC Polyclonal Antibody enables researchers to study the function and regulation of RhoC, providing insights into its potential as a therapeutic target for cancer treatment.Overall, the RHOC Polyclonal Antibody is a crucial tool for investigating the role of RhoC in cancer biology and may contribute to the development of novel therapeutic strategies aimed at inhibiting tumor metastasis and invasion.
Product Name:
RhoC Polyclonal Antibody
SKU:
CAB21798
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 94-193 of human RhoC (NP_786886.1).
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Purification Method:
Affinity purification
Gene ID:
389
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat heart, using RhoC Rabbit pAb (CAB21798) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
