The RhoA/RhoB/RhoC Rabbit Monoclonal Antibody (CAB4855) is a valuable tool for researchers studying Rho GTPases, key signaling proteins involved in cell migration, adhesion, and cell cycle progression. This antibody, generated in rabbits, is highly specific to the RhoA, RhoB, and RhoC proteins, making it ideal for Western blot and immunohistochemistry applications.Rho GTPases are critical regulators of cytoskeletal dynamics and are implicated in various cellular processes, including cell morphology, motility, and cell division.
Dysregulation of Rho GTPases has been linked to cancer progression, metastasis, and other diseases, making them attractive targets for therapeutic intervention.This antibody allows for the detection and analysis of RhoA, RhoB, and RhoC in different cell types and tissues, providing valuable insight into their function and signaling pathways. Its high specificity and sensitivity make it a reliable tool for researchers interested in exploring the role of Rho GTPases in cancer biology, cell biology, and other related fields.
Product Name:
RHOA/RHOB/RHOC Rabbit Monoclonal Antibody
SKU:
CAB4855
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-193 of human RHOA/RHOB/RHOC (P08134).
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Purification Method:
Affinity purification
Gene ID:
389/387/388
Clone Number:
ARC0273
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using RHOA/RHOB/RHOC Rabbit mAb (CAB4855) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
