The RhoA Polyclonal Antibody (CAB13947) is a valuable tool for researchers studying the RhoA protein, a key regulator of cell migration, adhesion, and cytoskeletal dynamics. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it suitable for use in Western blot applications.RhoA is a critical signaling molecule involved in a variety of cellular processes, including cell shape changes, cell movement, and cell division. Dysregulation of RhoA signaling has been linked to various diseases, including cancer, cardiovascular disorders, and neurological conditions.
By targeting RhoA with this polyclonal antibody, researchers can gain insights into its function and explore its potential as a therapeutic target in these disease contexts.This antibody enables the detection and analysis of RhoA protein levels in different cell types, providing valuable information for studies in cell biology, cancer research, and drug development. By understanding the role of RhoA in cellular processes and disease pathways, researchers can identify new strategies for treating and managing RhoA-related disorders.
Product Name:
RhoA Rabbit Polyclonal Antibody
SKU:
CAB13947
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 94-193 of human RhoA (NP_001655.1).
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified.
Purification Method:
Affinity purification
Gene ID:
387
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RhoA Rabbit pAb (CAB13947) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
