The RHOA Polyclonal Antibody (CAB0272) is a valuable tool for researchers studying the RHOA protein, a key player in cell migration, cytoskeletal dynamics, and cell polarity. This antibody, raised in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to RHOA, researchers can effectively detect and analyze the protein in various cell types, making it an essential tool for studies in cell biology and cancer research.RHOA is a member of the Rho family of GTPases and is involved in signaling pathways that regulate cell shape, motility, and proliferation.
Dysregulation of RHOA activity has been implicated in various diseases, including cancer, cardiovascular disorders, and neurological conditions. Therefore, understanding the function and regulation of RHOA is critical for developing targeted therapies and interventions for these diseases.Overall, the RHOA Polyclonal Antibody (CAB0272) is a reliable reagent for researchers investigating the role of RHOA in cellular processes and disease pathogenesis. Its high specificity and sensitivity make it an essential tool in the study of signaling pathways and potential therapeutic targets related to RHOA.
Product Name:
RhoA Rabbit Polyclonal Antibody
SKU:
CAB0272
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 94-193 of human RhoA (NP_001655.1).
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified.
Purification Method:
Affinity purification
Gene ID:
387
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RhoA Rabbit pAb (CAB0272) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
