The RHEBL1 Polyclonal Antibody (PACO39970) is a valuable tool for researchers studying the RHEBL1 protein, a key regulator of cell growth and metabolism. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By binding to RHEBL1, this antibody enables accurate detection and analysis of the protein in various cell types, facilitating research in fields such as cell biology, cancer, and metabolic disorders.
RHEBL1, a member of the Ras superfamily of small GTPases, is involved in the mTOR signaling pathway, which plays a crucial role in cell growth, proliferation, and survival. Dysregulation of RHEBL1 has been linked to various diseases, including cancer and metabolic syndromes, making it a promising target for therapeutic interventions. Investigating the function of RHEBL1 is essential for gaining insights into its role in disease pathogenesis and exploring new treatment strategies.
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO39970 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human appendix tissue using PACO39970 at dilution of 1:100.
Background:
Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2.
Synonyms:
GTPase RhebL1 (Ras homolog enriched in brain like-1 c) (RhebL1c) (Ras homolog enriched in brain-like protein 1) (Rheb-like protein 1) (Rheb2), RHEBL1
UniProt Protein Function:
RHEBL1: Binds GTP and exhibits intrinsic GTPase activity. May activate NF-kappa-B-mediated gene transcription. Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. Belongs to the small GTPase superfamily. Rheb family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: G protein, monomeric, Rheb; G protein, monomeric; G proteinChromosomal Location of Human Ortholog: 12q13.12Cellular Component: cytoplasmMolecular Function: GTP binding; protein bindingBiological Process: activation of NF-kappaB transcription factor; TOR signaling pathway
