The RHD Polyclonal Antibody (CAB15091) is a powerful tool for researchers studying the Rhesus D (RHD) protein, an important antigen involved in blood compatibility and transfusion medicine. This antibody, produced in rabbits, is highly specific to human RHD samples and has been validated for use in Western blot applications. By binding to the RHD protein, it allows for accurate detection and analysis in a variety of cell types, making it ideal for studies in immunology, hematology, and transfusion science.The RHD protein is crucial in determining an individual's blood type, particularly the presence or absence of the Rh factor.
Understanding the function and variability of the RHD antigen is essential for safe blood transfusions and pregnancies, as well as for diagnosing conditions like hemolytic disease of the newborn. Research on the RHD protein can also provide insights into autoimmune diseases and the development of targeted therapies. Overall, the RHD Polyclonal Antibody is a valuable tool for research aiming to unravel the complexities of the RHD protein and its implications in blood typing, transfusion reactions, and related medical conditions.
Product Name:
RHD Rabbit Polyclonal Antibody
SKU:
CAB15091
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human RHD (NP_001121163.1).
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene, which encodes the RhD protein, and a second gene that encodes both the RhC and RhE antigens on a single polypeptide. The two genes, and a third unrelated gene, are found in a cluster on chromosome 1. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6007
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using RHD Rabbit pAb (CAB15091) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
