The RGS22 Polyclonal Antibody (PAC016978) is a valuable tool for researchers studying RGS22, a member of the Regulator of G protein signaling (RGS) protein family that plays a critical role in modulating signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.RGS22 is known for its involvement in regulating G protein-coupled receptor signaling, which is essential for various cellular processes such as neurotransmission, hormone secretion, and immune response. By targeting RGS22 with this antibody, researchers can detect and analyze the expression of this protein in different cell types, providing valuable insights into its function and potential implications in diseases like cancer, neurological disorders, and cardiovascular conditions.
The RGS22 Polyclonal Antibody is a valuable tool for investigations into the molecular mechanisms underlying RGS22 function and its role in cellular signaling pathways. Its specificity and reliability make it an ideal choice for studies in cell biology, pharmacology, and drug development aimed at targeting RGS22 for therapeutic interventions.
Antibody Name:
RGS22 Antibody (PACO16978)
Antibody SKU:
PACO16978
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Fusion protein of human RGS22
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO16978(RGS22 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO16978(RGS22 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200).
Background:
RGS22 (regulator of G-protein signaling 22), also known as FLJ75004, PRTD-NY2, FLJ40080, MGC102908 or DKFZp434I092, is a novel 1264 amino acid, regulator of G-protein signaling specific to to testis. RGS22 inhibits signal transduction and contains two isoforms as a result of alternative splicing. RGS22 is found in spermatogenic cells and Leydig cells, and may be involved in the translocation of GNA13 from the cytoplasm to the nucleus during spermiogenesis. RGS22 contains two RGS domains: RGS1 and RGS2, and the gene encoding RGS22 maps to human chromosome 8q22.2.
Synonyms:
regulator of G-protein signaling 22
UniProt Protein Function:
RGS22: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GAPs, RGS; Cancer Testis Antigen (CTA); GAPsChromosomal Location of Human Ortholog: 8q22.2Cellular Component: cytoplasm; plasma membraneMolecular Function: GTPase activator activity
