The RGS2 Polyclonal Antibody (CAB1795) is a vital tool for researchers studying RGS2, a protein involved in regulating G-protein signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding specifically to the RGS2 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component for studies in cell signaling and drug development.RGS2, or Regulator of G-Protein Signaling 2, is known for its role in modulating cellular responses to various stimuli by accelerating the hydrolysis of GTP bound to G-proteins. This function makes RGS2 a key player in regulating important signaling pathways that control processes such as cell proliferation, migration, and differentiation.
Research into RGS2 has implications for understanding diseases like cancer, cardiovascular disorders, and neurological conditions, where dysregulation of G-protein signaling pathways can contribute to pathogenesis.By using the RGS2 Polyclonal Antibody (CAB1795), researchers can gain valuable insights into the intricate mechanisms of G-protein signaling and its impact on cellular behavior. This antibody's specificity and reliability make it an indispensable tool for investigating the role of RGS2 in health and disease, ultimately leading to the development of targeted therapies and interventions.
Product Name:
RGS2 Polyclonal Antibody
SKU:
CAB1795
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-211 of human RGS2 (NP_002914.1).
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.
Purification Method:
Affinity purification
Gene ID:
5997
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human breast cancer using RGS2 Rabbit pAb (CAB1795) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
