RGS19 Antibody (PACO49946)
- SKU:
- PACO49946
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
RGS19 Antibody (PACO49946)
The RGS19 Polyclonal Antibody (PAC049946) is a crucial tool for researchers studying RGS19, a protein involved in intracellular signaling pathways related to G-protein-coupled receptors. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications, allowing for the detection and analysis of RGS19 in various cell types.RGS19, also known as Regulator of G-protein Signaling 19, plays a key role in the regulation of G protein signaling, which is essential for various physiological processes including cell growth, differentiation, and neurotransmission.
Dysregulation of RGS19 has been implicated in diseases such as cancer, cardiovascular disorders, and neurological conditions, making it a promising target for therapeutic interventions.By using the RGS19 Polyclonal Antibody, researchers can further explore the functions and mechanisms of RGS19 in disease development and progression, paving the way for the development of novel treatments and diagnostics. This antibody is a valuable asset for studies in pharmacology, cell biology, and drug discovery, providing insights into the complex signaling networks controlled by RGS19.
| Antibody Name: | RGS19 Antibody (PACO49946) |
| Antibody SKU: | PACO49946 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Regulator of G-protein signaling 19 protein (1-87AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO49946 at dilution of 1:100. |
 | Immunofluorescent analysis of HepG2 cells using PACO49946 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO49946 at dilution of 1:100. |
| Background: | Inhibits signal transduction by increasing the GTPase activity of G protein α subunits thereby driving them into their inactive GDP-bound form. Binds to G-α subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-α is inhibited by phosphorylation and palmitoylation of the G-protein. |
| Synonyms: | Regulator of G-protein signaling 19 (RGS19) (G-alpha-interacting protein) (GAIP), RGS19, GAIP GNAI3IP |
| UniProt Protein Function: | RGS19: inhibits signal transduction by increasing the GTPase activity of g protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(I)a3 > G(I)a1 > G(O)a >> G(Z)a/G(I)a2. Activity on G(Z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein. |
| UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 20q13.33 Cellular Component: beta-catenin destruction complex; cell cortex; cytoplasmic membrane-bound vesicle; cytoplasmic microtubule; Golgi apparatus; heterotrimeric G-protein complex; membrane; postsynaptic density Molecular Function:beta-catenin binding; GTPase activator activity; protein binding; protein kinase binding Biological Process: cell death; cell differentiation; dorsal/ventral axis specification; G-protein coupled receptor protein signaling pathway; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction |
| NCBI Summary: | G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P49795 |
| NCBI GenInfo Identifier: | 1730186 |
| NCBI Gene ID: | 10287 |
| NCBI Accession: | P49795.1 |
| UniProt Secondary Accession: | P49795,Q53XN0, Q8TD60, A8K216, E1P5G9, |
| UniProt Related Accession: | P49795 |
| Molecular Weight: | 24,636 Da |
| NCBI Full Name: | Regulator of G-protein signaling 19 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 19 |
| NCBI Official Symbol: | RGS19Â Â |
| NCBI Official Synonym Symbols: | GAIP; RGSGAIPÂ Â |
| NCBI Protein Information: | regulator of G-protein signaling 19 |
| UniProt Protein Name: | Regulator of G-protein signaling 19 |
| UniProt Synonym Protein Names: | G-alpha-interacting protein; GAIP |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS19Â Â |
| UniProt Entry Name: | RGS19_HUMAN |
Related Products
Mouse Regulator of G-protein signaling 19 (Rgs19) ELISA Kit (MOEB2206)
Rat Regulator of G-protein signaling 19 (Rgs19) ELISA Kit (RTEB1538)
Human Regulator of G-protein signaling 19 (RGS19) ELISA Kit (HUEB2461)
Bovine Regulator of G-protein signaling 19 (RGS19) ELISA Kit (BOEB1079)
