| UniProt Protein Function: | RGS18: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha- 2, G(i) alpha-3 and G(q) alpha.Protein type: GAPs, RGS; GAPsChromosomal Location of Human Ortholog: 1q31.2Cellular Component: cytoplasm; plasma membraneMolecular Function: GTPase activator activityBiological Process: G-protein coupled receptor protein signaling pathway; positive regulation of GTPase activity |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9NS28 |
| NCBI GenInfo Identifier: | 18640750 |
| NCBI Gene ID: | 64407 |
| NCBI Accession: | NP_570138.1 |
| UniProt Secondary Accession: | Q9NS28,B2RD23 |
| UniProt Related Accession: | Q9NS28 |
| Molecular Weight: | 27,582 Da |
| NCBI Full Name: | regulator of G-protein signaling 18 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 18 |
| NCBI Official Symbol: | RGS18Â Â |
| NCBI Official Synonym Symbols: | RGS13Â Â |
| NCBI Protein Information: | regulator of G-protein signaling 18; regulator of G-protein signalling 13; regulator of G-protein signalling 18 |
| UniProt Protein Name: | Regulator of G-protein signaling 18 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS18Â Â |
| UniProt Entry Name: | RGS18_HUMAN |
