RGS14 Rabbit Polyclonal Antibody (CAB9962)
- SKU:
- CAB9962
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | RGS14 Rabbit Polyclonal Antibody |
SKU: | CAB9962 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 230-510 of human RGS14 (NP_006471.2). |
Sequence: | PPVE GPGG RPLR KSFR RELG GTAN AALR RESQ GSLN SSAS LDLG FLAF VSSK SESH RKSL GSTE GESE SRPG KYCC VYLP DGTA SLAL ARPG LTIR DMLA GICE KRGL SLPD IKVY LVGN EQAL VLDQ DCTV LADQ EVRL ENRI TFEL ELTA LERV VRIS AKPT KRLQ EALQ PILE KHGL SPLE VVLH RPGE KQPL DLGK LVSS VAAQ RLVL DTLP GVKI SKAR DKSP CRSQ GCPP RTQD KATH PPPA SPSS LVKV PSSA TGKR QTCD IEGL VELL NRVQ S |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | RGS14 |
Positive Sample: | SH-SY5Y,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus, PML body, centrosome, cytoskeleton, dendrite, dendritic spine, microtubule organizing center, postsynaptic cell membrane, postsynaptic density, spindle, spindle pole, synapse. |
Calculated MW: | 61kDa |
Observed MW: | 54kDa |
This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Purification Method: | Affinity purification |
Gene ID: | 10636 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |