The RGS10 Polyclonal Antibody (CAB9948) is a valuable tool for researchers studying RGS10, a protein involved in intracellular signaling pathways. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the RGS10 protein, this antibody allows for precise detection and analysis in various cell types, making it ideal for investigations in cell signaling and drug development research.RGS10, a regulator of G-protein signaling, plays a crucial role in modulating cellular responses to extracellular stimuli by inhibiting G-protein signaling pathways.
Understanding the function of RGS10 is essential for uncovering its involvement in disease development and progression, particularly in conditions such as cancer, cardiovascular diseases, and neurodegenerative disorders. By targeting RGS10, researchers can elucidate its impact on cell signaling cascades and potentially identify novel therapeutic targets for various pathological conditions.
Product Name:
RGS10 Rabbit Polyclonal Antibody
SKU:
CAB9948
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-181 of human RGS10 (NP_001005339.1).
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
6001
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using RGS10 antibody (CAB9948) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
